An invasive mole can penetrate the full thickness of the uterine wall and rupture, resulting in severe intra-abdominal or vaginal bleeding. Invasive moles can also metastasize, most commonly to the vagina and lung. This may be confusing since women with proven invasive moles who have metastases may also have choriocarcinoma . Although an invasive mole is locally more aggressive than a non-invasive mole, it is no more likely to be complicated by choriocarcinoma.
Choriocarcinoma can spread virtually anywhere in the body but most commonly spreads to the lung, the lower genital tract (cervix, vagina and vulva), the brain, liver, kidney and the gastrointestinal tract.
